Quantitative fiber tracking after perinatal hypoxic-ischemia and neurodevelopmental outcome at 2 years

Hypoxic-ischemic encephalopathy (HIE) is an important cause of mortality and morbidity in infants who are born at term. Previous studies correlate abnormal signal intensities (SI) on conventional MRI with neurodevelopmental outcome (1-3). SI changes in the posterior limb of the internal capsule (PLIC) on Diffusion-weighted Imaging are an accurate predictor of neuromotor outcome in term newborns with HIE (4). Quantitative fibertracking is a feasible tool in studying the asphyxiated neonatal brain (5). However, investigations to determine whether fibertract anomalies correlate with neonatal outcome are lacking. The aim of this study was to assess the relationship between the volume of the fibers traced through the PLIC and neurodevelopmental outcome at 2 years in term neonates with perinatal HIE.

@Misc { PBVRP08,
  author       = "Palen, R.L. van der and Op denBuijs, J. and Vilanova, Anna and Roos, F.G. and Pul, C. van",
  title        = "Quantitative fiber tracking after perinatal hypoxic-ischemia and neurodevelopmental outcome at 2 years",
  howpublished = "SPR",
  year         = "2008",
  url          = "http://graphics.tudelft.nl/Publications-new/2008/PBVRP08"
}