Fiber Tracking in Newborns with Perinatal Hypoxic-Ischemia at Birth and at 3 Months

The purpose of our study was to retrospectively investigate the feasibility of using fiber tracking to detect disturbances in white matter development in newborns suffering from hypoxic-ischemia, at birth and at the age of 3 months. Diffusion Tensor Images were obtained from full-term newborns, 7 with normal MRI and 10 with pathology related to perinatal hypoxic-ischemia. All parents gave informed consent. Visualization of white matter tracts was investigated using a volume tracing and quantification technique. Fiber tracking was useful to study the neonatal brain. Pathology resulted in different fiber patterns, compared to normal. Frequently affected were the corona radiata fibers.

@Article { PBVRW06a,
  author       = "Pul, C. van and Op denBuijs, J. and Vilanova, Anna and Roos, F.G. and Wijn, P.F.F.",
  title        = "Fiber Tracking in Newborns with Perinatal Hypoxic-Ischemia at Birth and at 3 Months",
  journal      = "Radiology",
  number       = "1",
  volume       = "240",
  pages        = "203-214",
  year         = "2006",
  url          = "http://graphics.tudelft.nl/Publications-new/2006/PBVRW06a"
}