Integrated visualization of multi-angle bioluminescence imaging and micro ct

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

@InProceedings { KDBPKQLRL07a,
  author       = "Kok, Peter and Dijkstra, J. and Botha, Charl P. and Post, Frits H. and Kaijzel, E.L. and Que, I. and Lowik,
                  C.W.G.M. and Reiber, J.H.C. and Lelieveldt, Boudewijn P.F.",
  title        = "Integrated visualization of multi-angle bioluminescence imaging and micro ct",
  booktitle    = "Proc. SPIE Medical Imaging 2007",
  volume       = "6509",
  year         = "2007",
  editor       = "Kevin R. Cleary and Michael I. Miga",
  note         = "2007.01.01",
  url          = "http://graphics.tudelft.nl/Publications-new/2007/KDBPKQLRL07a"
}