Integrated visualization of multi-angle bioluminescence imaging and micro ct

Peter Kok, J. Dijkstra, Charl P. Botha, Frits H. Post, E.L. Kaijzel, I. Que, C.W.G.M. Lowik, J.H.C. Reiber, Boudewijn P.F. Lelieveldt
Proc. SPIE Medical Imaging 2007, Volume 6509 - 2007
Download the publication : KDBPKQLRL07a.pdf [1Mo]  
This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

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BibTex references

@InProceedings { KDBPKQLRL07a,
  author       = "Kok, Peter and Dijkstra, J. and Botha, Charl P. and Post, Frits H. and Kaijzel, E.L. and Que, I. and Lowik,
                  C.W.G.M. and Reiber, J.H.C. and Lelieveldt, Boudewijn P.F.",
  title        = "Integrated visualization of multi-angle bioluminescence imaging and micro ct",
  booktitle    = "Proc. SPIE Medical Imaging 2007",
  volume       = "6509",
  year         = "2007",
  editor       = "Kevin R. Cleary and Michael I. Miga",
  note         = "2007.01.01",
  url          = ""

Other publications in the database

» Peter Kok
» J. Dijkstra
» Charl P. Botha
» Frits H. Post
» E.L. Kaijzel
» C.W.G.M. Lowik
» J.H.C. Reiber
» Boudewijn P.F. Lelieveldt