MRI-based visualisation of orbital fat deformation during eye motion

Orbital fat, or the fat behind the eye, plays an important role in eye movements. In order to gain a better understanding of orbital fat mobility during eye motion, MRI datasets of the eyes of two healthy subjects were acquired respectively in seven and fourteen different directions of gaze. After semi-automatic rigid registration, the Demons deformable registration algorithm was used to derive time-dependent three-dimensional deformation vector fields from these datasets. Visualisation techniques were applied to these datasets in order to investigate fat mobility in specific regions of interest in the first subject. A qualitative analysis of the first subject showed that in two of the three regions of interest, fat moved half as much as the embedded structures. In other words, when the muscles and the optic nerve that are embedded in the fat move, the fat partly moves along with these structures and partly flows around them. In the second subject, a quantitative analysis was performed which showed a relation between the distance behind the sclera and the extent to which fat moves along with the optic nerve.

@InProceedings { BGSRWHSP07a,
  author       = "Botha, Charl P. and Graaf, Thijs de and Schutte, Sander and Root, Ronald and Wielopolski, Piotr and Helm,
                  Frans C.T. van der and Simonsz, Huib and Post, Frits H.",
  title        = "MRI-based visualisation of orbital fat deformation during eye motion",
  booktitle    = "Visualization in Medicine and Life Sciences",
  year         = "2007",
  note         = "2007.04.20",
  url          = "http://graphics.tudelft.nl/Publications-new/2007/BGSRWHSP07a"
}