Thomas Höllt | Computer Graphics and Visualization

Assistant Professor for Visualization at Leiden Computational Biology Center at LUMC
Visiting Researcher at Computer Graphics and Visualization group at TU Delft
Room E6.200, Building 28
E-mail: T.Hollt-1@tudelft.nl
Website: http://www.thomashollt.com

Research

My main research is on the visual analysis of high dimensional data with a strong focus on the Cytosplore project. Cytosplore is a framework for visual analysis of single cell data acquired using Mass Cytometry. The data consists of high dimensional expression data for single cells taken through blood- or tissue samples.

Previously I worked on visualization of ensemble data and uncertainty, mostly for ocean forecasts, but also in other geological and geophysical applications. I developed Ovis, a framework for visual analysis of ocean forecasts.

Available Master Thesis Projects

We have open projects within the Cytosplore project including a project on classification of cellular expression data through dimensionality reduction. If you’re interested in working with me on this or other projects involving biological visualisation for your master thesis project, please contact me directly, or Dr. A. Vilanova to discuss the possibilities.

Recent Publications

Publications in 2020

GPGPU Linear Complexity t-SNE Optimization

Nicola Pezzotti, Alexander Mordvinstev, Thomas Höllt, Boudewijn P.F. Lelieveldt, Elmar Eisemann, Anna Vilanova

IEEE Transactions on Visualization and Computer Graphics (Proceedings of VAST 2019), Volume 26, Number 1 - 2020

Publications in 2019

CyTOFmerge: Integrating mass cytometry data across multiple panels

Tamim Abdelaal, Thomas Höllt, Vincent van Unen, Boudewijn P.F. Lelieveldt, Frits Koning, Marcel Reinders, Ahmed Mahfouz

Bioinformatics, Volume btz180 - 2019

Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System

Thomas Höllt, Nicola Pezzotti, Vincent van Unen, Na Li, Frits Koning, Elmar Eisemann, Boudewijn P.F. Lelieveldt, Anna Vilanova

Dirk Bartz Prize for Visual Computing in Medicine 2019 (Eurographics Medical Prize) - 2019

Focus+Context Exploration of Hierarchical Embeddings

Thomas Höllt, Anna Vilanova, Nicola Pezzotti, Boudewijn P.F. Lelieveldt, Helwig Hauser

Computer Graphics Forum (Proceedings of Eurographics 2019), Volume 38, Number 3 - 2019

ImaCytE: Visual Exploration of Cellular Microenvironments for Imaging Mass Cytometry Data

Antonios Somarakis, Vincent van Unen, Frits Koning, Boudewijn P.F. Lelieveldt, Thomas Höllt

IEEE Transactions on Visualization and Computer Graphics - 2019

Memory CD4+ T Cells are Generated in the Human Fetal Intestine

Na Li, Vincent van Unen, Tamim Abdelaal, Nannan Guo, Sofya Kasatskaya, Kristin Ladell, James McLaren, Evgeniy Egorov, Mark Izraelson, Susana M. Chuva de Sousa Lopes, Thomas Höllt, Olga Britanova, Jeroen Eggermont, Noel de Miranda, Dmitriy Chudakov, David Price, Boudewijn P.F. Lelieveldt, Frits Koning

Nature Immunology, Volume 20, Number 3, page 301--312 - 2019

Predicting cell types in single cell mass cytometry data

Tamim Abdelaal, Vincent van Unen, Thomas Höllt, Frits Koning, Marcel Reinders, Ahmed Mahfouz

Cytometry Part A - 2019

The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Impacts Survival

Saskia J Santegoets, Vanessa J van Ham, Ilina Ehsan, Pornpimol Charoentong, Chantal L Duurland, Vincent van Unen, Thomas Höllt, Lilly-Ann van der Velden, Sylvia I. van Egmond, Kim Kortekaas, Peggy J de Vos van Steenwijk, Mariette IE van Poelgeest , Marij J P Welters, Sjoerd H van der Burg

Clinical Cancer Research, Volume 25, Number 1 - jan 2019

Publications in 2018